Stem Cells as a symptom- and strUcture-modifying Treatment for knee OsteoaRthritis- the SCUlpTOR trial.

干细胞作为膝骨关节炎的症状和结构改善治疗 - SCUlpTOR 试验。

• 批准号: nhmrc : GNT1162874
• 金额: $ 198.28万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/stem-cells-symptom-sculptor-trial/1379260
• 关键词: Stem; Cells; symptom; strUcture; modifying

Knee osteoarthritis (OA) is a major source of disability with no known cure. In order to address this gap, safe and effective treatments that reduce symptoms AND slow structural disease progression are needed. Whilst no disease-modifying agent has been approved to date, stem cells have biologic potential in this context. This trial will evaluate the efficacy of stem cell injections for reducing pain and slowing disease progression in knee OA compared to placebo.

膝关节骨关节炎（OA）是一个主要的残疾来源，没有已知的治愈。为了解决这一差距，需要安全有效的治疗方法来减轻症状并减缓结构性疾病进展。虽然迄今为止还没有疾病修饰剂被批准，但干细胞在这种情况下具有生物学潜力。本试验将评估干细胞注射与安慰剂相比在减轻膝关节OA疼痛和减缓疾病进展方面的疗效。