Structural characterisation function analyses of type I interferon-receptor interactions

I型干扰素-受体相互作用的结构表征功能分析

• 批准号: nhmrc : 606931
• 负责人: Dr Hugh Reid
• 金额: $ 34.54万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structural-characterisation-function-receptor-interactions/76559
• 关键词: Structural; characterisation; function; analyses; type

The interferons are an essential component of the body's response to infectious and inflammatory disease and cancer. In order to design the best therapeutic approaches to modulate interferon activity, we need a defined understanding of how IFN binds to its receptor on target cells and activates its functions. This project will characterize these interactions in cells, mice and molecules with x-ray crystallography and the synchrotron to solve the structure and facilitate informed drug design.

干扰素是人体对传染病、炎症性疾病和癌症反应的重要组成部分。为了设计最佳的治疗方法来调节干扰素的活性，我们需要明确地了解干扰素是如何与靶细胞上的受体结合并激活其功能的。该项目将利用X射线结晶学和同步加速器来表征细胞、小鼠和分子中的这些相互作用，以解决结构问题并促进知情的药物设计。