Structural characterisation function analyses of type I interferon-receptor interactions

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The interferons are an essential component of the body's response to infectious and inflammatory disease and cancer. In order to design the best therapeutic approaches to modulate interferon activity, we need a defined understanding of how IFN binds to its receptor on target cells and activates its functions. This project will characterize these interactions in cells, mice and molecules with x-ray crystallography and the synchrotron to solve the structure and facilitate informed drug design.