An investigation into the adaptive immune response in Celiac Disease

乳糜泻（CD）是一种自身免疫性疾病，由摄入小麦麸质或来自黑麦和大麦的相关蛋白质引发，影响约1%的人口，导致小肠组织损伤。唯一有效的治疗方法是终生严格坚持无麸质饮食。我们的项目旨在了解，在分子水平上，免疫系统的组成部分和谷蛋白是如何相互作用，触发导致乳糜泻症状的免疫反应的。

Celiac Disease (CD), an autoimmune-like disease that is triggered by the ingestion of dietary wheat gluten, or related proteins from rye and barely, affects ~1% of the population, causing tissue damage in the small intestine. The only available treatment is strict adherence to a lifelong gluten free diet. Our project aims to understand, at the molecular level, how components of the immune system and gluten interact to trigger the immune response that leads to CD symptoms.