An investigation into the adaptive immune response in Celiac Disease

乳糜泻适应性免疫反应的研究

• 批准号: nhmrc : 1085875
• 负责人: Dr Hugh Reid
• 金额: $ 39.82万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/an-investigation-adaptive-celiac-disease/519106
• 关键词: investigation; into; adaptive; immune; response

Celiac Disease (CD), an autoimmune-like disease that is triggered by the ingestion of dietary wheat gluten, or related proteins from rye and barely, affects ~1% of the population, causing tissue damage in the small intestine. The only available treatment is strict adherence to a lifelong gluten free diet. Our project aims to understand, at the molecular level, how components of the immune system and gluten interact to trigger the immune response that leads to CD symptoms.

乳糜泻 (CD) 是一种类似自身免疫性疾病，由摄入膳食小麦麸质或黑麦和黑麦中的相关蛋白质引发，影响约 1% 的人口，导致小肠组织损伤。唯一可用的治疗方法是严格遵守终生无麸质饮食。我们的项目旨在从分子水平上了解免疫系统的组成部分和麸质如何相互作用以触发导致克罗恩病症状的免疫反应。