Structural characterisation of SNARE protein complexes involved in insulin-regulated glucose transport

参与胰岛素调节葡萄糖转运的 SNARE 蛋白复合物的结构表征

• 批准号: nhmrc : 569864
• 负责人: Dr Andrew Whitten
• 金额: $ 21.39万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structural-characterisation-snare-glucose-transport/116134
• 关键词: Structural; characterisation; SNARE; protein; complexes

Insulin-regulated glucose transportation is defective in type 2 diabetes, a disease that is a major health problem worldwide and in some cases can lead to death. The aim of this work is to investigate the molecular structure and function of proteins critical to the transportation and delivery of glucose to muscle and fat cells, which will lead to the validation of new therapeutic targets and the development of new treatments for diabetes.

胰岛素调节的葡萄糖转运在2型糖尿病中是有缺陷的，2型糖尿病是一种世界范围内的主要健康问题，在某些情况下可能导致死亡。这项工作的目的是研究蛋白质的分子结构和功能，这些蛋白质对葡萄糖向肌肉和脂肪细胞的运输和递送至关重要，这将导致新的治疗靶点的验证和糖尿病新疗法的开发。