Molecular dissection of the Munc18c:Syntaxin4 complex required for insulin-regulated exocytosis in adipocytes

脂肪细胞中胰岛素调节胞吐作用所需的 Munc18c:Syntaxin4 复合物的分子解剖

• 批准号: nhmrc : 1066069
• 负责人: Dr Andrew Whitten
• 金额: $ 40.08万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-dissection-munc18csyntaxin4-exocytosis-adipocytes/455218
• 关键词: Molecular; dissection; Munc18c; Syntaxin4; complex

When blood glucose levels are high, insulin signals to fat and muscle cells to remove glucose from the blood. The uptake of glucose relies on membrane fusion events that deliver a specific glucose transporter protein to the cell surface in response to insulin signals. This process is affected in Type II diabetes. Our research will characterise the regulation of these membrane fusion events and will be important for understanding how insulin signals are communicated in health and disease.

当血糖水平较高时，胰岛素会向脂肪和肌肉细胞发出信号，以去除血液中的葡萄糖。葡萄糖的摄取依赖于膜融合事件，膜融合事件响应胰岛素信号将特定的葡萄糖转运蛋白递送到细胞表面。这一过程在 II 型糖尿病中受到影响。我们的研究将表征这些膜融合事件的调节，对于理解胰岛素信号在健康和疾病中如何传递非常重要。