Structural and functional role of HIV-1 gp41 terminal interactions in the membrane fusion mechanism
Structural and functional role of HIV-1 gp41 terminal interactions in the membrane fusion mechanism
批准号:
nhmrc : 543125
负责人:
A/Pr Heidi Drummer
金额:
$35.32万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2009
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2009-01-01 至 2011-12-31
中文摘要
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英文摘要
Approximately 40 million individuals are currently living with HIV. The viral glycoproteins, gp120-gp41, mediate the first stage of infection, membrane fusion, and thus serve as targets for vaccines and antiviral agents. Thi proposal seeks to assess the structure and function of a potential new drug target in gp120-gp41. These studies may lead to the identification of a new antiviral that blocks membrane fusion. Such agents can be added to antiviral drug cocktails for more effective therapy.
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