Role of the hepatitis C virus glycoprotein E2 variable regions in viral entry and antibody mediated neutralization.

丙型肝炎病毒糖蛋白 E2 可变区在病毒进入和抗体介导的中和中的作用。

• 批准号: nhmrc : 543113
• 负责人: A/Pr Heidi Drummer
• 金额: $ 36.17万
• 依托单位: Macfarlane Burnet Institute for Medical Research and Public Health
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-hepatitis-c-mediated-neutralization/82542
• 关键词: Role; hepatitis; virus; glycoprotein; E2

The first stage of Hepatitis C Virus replication involves attaching to liver cells. This study is aimed at understanding how the virus attaches to liver cells and how antibodies raised during infection, block this interaction. In addition, this study aims to examine how the virus modulates its structure to evade the immne system, allowing the virus to establish chronic infections. The results of this study will guide future vaccine design for HCV.

丙型肝炎病毒复制的第一阶段涉及附着在肝细胞上。这项研究旨在了解病毒如何附着在肝细胞上，以及感染过程中产生的抗体如何阻止这种相互作用。此外，本研究旨在研究病毒如何调节其结构以逃避免疫系统，从而使病毒建立慢性感染。本研究的结果将指导未来的HCV疫苗设计。