Charting the brain's wiring over the human lifespan

绘制人类一生中大脑的接线图

• 批准号: DE240101035
• 负责人: Dr Remika Mito
• 金额: $ 31.28万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE240101035
• 关键词: Charting; brain; wiring; over; human

This project aims to produce a large-scale model of brain wiring over the human lifespan by utilising normative modelling approaches on state-of-the-art diffusion magnetic resonance imaging (diffusion MRI) data. This project expects to generate new understanding of how the brain's connections change with age in healthy individuals. Expected outcomes of this project include a reference chart for healthy brain wiring, and major advances in diffusion MRI data harmonisation approaches. This should provide significant benefits for the translation of advanced diffusion MRI methods, as normative charts for brain wiring will be made broadly available. This could have broad implications for interpreting individual diffusion MRI scans in future.

该项目旨在通过利用最先进的扩散磁共振成像（弥散MRI）数据的规范建模方法，在人类的一生中产生一个大规模的大脑线路模型。该项目希望对健康个体的大脑连接如何随年龄变化产生新的认识。该项目的预期成果包括健康大脑线路的参考图表，以及扩散MRI数据协调方法的重大进展。这将为先进的扩散MRI方法的翻译提供显著的好处，因为大脑线路的规范图表将广泛可用。这可能对未来解释个体扩散MRI扫描具有广泛的意义。