A structural understanding of class B G protein-coupled receptor function

B 类 G 蛋白偶联受体功能的结构理解

• 批准号: nhmrc : GNT1120919
• 负责人: Dr Sebastian Furness
• 金额: $ 128.96万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structural-understanding-class-receptor-function/1347172
• 关键词: structural; understanding; class; protein; coupled

G protein-coupled receptors (GPCRs) are the largest family of cell surface proteins that enable communication from external signals to the inside of cells of the body. Class B GPCRs are a therapeutically important subclass of these receptors and they play crucial roles in bone and energy homeostasis, cardiovascular control and immune response. This grant will uncover fundamental knowledge on how these receptors work, and will enhance future development of therapeutics.

G蛋白偶联受体（GPCR）是细胞表面蛋白质的最大家族，能够将外部信号传递到身体细胞内部。B类GPCR是这些受体的治疗上重要的亚类，并且它们在骨和能量稳态、心血管控制和免疫应答中起关键作用。这项资助将揭示这些受体如何工作的基本知识，并将促进未来治疗的发展。