The molecular basis for efficacy at G protein coupled receptors

G 蛋白偶联受体功效的分子基础

• 批准号: FT180100543
• 负责人: Dr Sebastian Furness
• 金额: $ 49.31万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT180100543
• 关键词: molecular; basis; efficacy; protein; coupled

This project aims to investigate the molecular steps underlying the relationship between sensing by signal-transmitting proteins on the cell surface called G protein-coupled receptors and cellular response. The project aims to build on studies that have sought to understand the primary, molecular basis for this cellular volume control. This project seeks to use these novel approaches to fill this knowledge gap, providing a deeper understanding of how physiology and medicines work. The project expects to expand fundamental understanding of signal transmission at this receptor class. This project will deliver benefits including expanded basic knowledge and a contribution to future improvements in drug development.

本项目旨在研究细胞表面称为G蛋白偶联受体的信号传递蛋白的感知与细胞反应之间关系的分子步骤。该项目旨在建立在试图了解这种细胞体积控制的主要分子基础的研究基础上。该项目旨在使用这些新方法来填补这一知识空白，从而更深入地了解生理学和药物的工作原理。该项目预计将扩大对这类受体信号传输的基本理解。该项目将带来好处，包括扩大基础知识和促进未来药物开发的改进。