Understanding the structural basis for Family B G protein-coupled receptor function

了解 B 族 G 蛋白偶联受体功能的结构基础

• 批准号: nhmrc : 1061044
• 负责人: Dr Sebastian Furness
• 金额: $ 49.68万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-structural-basis-receptor-function/454867
• 关键词: Understanding; structural; basis; Family; protein

G protein-coupled receptors (GPCRs) are the largest family of cell surface proteins that enable communication from external signals to the inside of cells of the body. Family B GPCRs are a therapeutically important subclass of these receptors and they play crucial roles in bone and energy homeostasis, cardiovascular control and immune response. This grant will uncover fundamental knowledge on how these receptors work, and will enhance future development of therapeutics.

G蛋白偶联受体（gpcr）是最大的细胞表面蛋白家族，能够实现从外部信号到身体细胞内部的通信。B家族gpcr是这些受体的重要治疗亚类，它们在骨骼和能量稳态、心血管控制和免疫反应中发挥重要作用。这项资助将揭示这些受体如何工作的基础知识，并将加强治疗方法的未来发展。