Structure-based Drug Design for Neuroprotection from Traditional Chinese Medicine

基于结构的中药神经保护药物设计

• 批准号: nhmrc : 1054172
• 负责人: Dr Chongyun Cheng
• 金额: $ 16.4万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structure-based-drug-chinese-medicine/112374
• 关键词: Structure; based; Drug; Design; Neuroprotection

In the proposed research, three novo approaches for drug discovery will be explored: 1) The important neurodegenerative disease relevant protein JNK3 crystals will be used as the probe to fish out the potential inhibitors from Traditional Chinese Medicine (TCM); 2) Instead of individual drug components, the mixture of TCM will be used directly; 3) The composition of a TCM library are not randomly chosen but have been used in China for hundreds to thousands of years in curing neurodegenerative disease.

在拟议的研究中，将探索三种新的药物发现方法：1）以重要的神经退行性疾病相关蛋白JNK3晶体为探针，从中药中找出潜在的抑制剂； 2）直接使用中药混合物，而不是单独的药物成分； 3）中药库的组成不是随机选择的，而是在中国用于治疗神经退行性疾病已有数百至数千年的历史。