Structure-based Drug Design for Neuroprotection from Traditional Chinese Medicine

在拟议的研究中，将探索三种新的药物发现方法：1)将以重要的神经退行性疾病相关蛋白JNK3晶体为探针，从中药中筛选出潜在的抑制剂；2)将直接使用中药的混合物，而不是单独的药物成分；3)中药库的成分不是随机选择的，而是被中国用于治疗神经退行性疾病已有数百至数千年的历史。

In the proposed research, three novo approaches for drug discovery will be explored: 1) The important neurodegenerative disease relevant protein JNK3 crystals will be used as the probe to fish out the potential inhibitors from Traditional Chinese Medicine (TCM); 2) Instead of individual drug components, the mixture of TCM will be used directly; 3) The composition of a TCM library are not randomly chosen but have been used in China for hundreds to thousands of years in curing neurodegenerative disease.