Structure based drug design of inhibitors of the cholesterol-dependent cytolysins and respiratory syncytial virus fusion

胆固醇依赖性溶细胞素和呼吸道合胞病毒融合抑制剂的基于结构的药物设计

• 批准号: nhmrc : 395532
• 负责人: Dr Susanne Feil
• 金额: $ 25.14万
• 依托单位: St. Vincent's Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structure-based-drug-virus-fusion/114619
• 关键词: Structure; based; drug; design; inhibitors

The aim of this work is to determine the three-dimensional atomic structures of proteins that play a role in infection by human pathogens. The structures will provide the basis for developing compounds that interfere with the function of these proteins and hence have potential as drugs to fight infection. The proteins being studied are required for the invasion of human tissues by pathogens; one group are toxins produced in bacterial infections such as pneumonia and meningitis while the other proteins to be studied are used by viruses to infect human cells.

这项工作的目的是确定在人类病原体感染中发挥作用的蛋白质的三维原子结构。这些结构将为开发干扰这些蛋白质功能的化合物提供基础，因此有可能作为抗感染药物。被研究的蛋白质是病原体侵入人体组织所必需的;一组是细菌感染（如肺炎和脑膜炎）产生的毒素，而其他被研究的蛋白质则被病毒用来感染人体细胞。