Subset Determination of Tissue-Resident T cell Memory

组织驻留 T 细胞记忆的子集测定

• 批准号: nhmrc : GNT1146711
• 负责人: Dr Laura Mackay
• 金额: $ 46.69万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/subset-determination-tissue-cell-memory/1348781
• 关键词: Subset; Determination; Tissue; Resident; cell

Immunity relies on white blood cells called T cells that circulate around the body and which are also found permanently lodged at body surfaces. It is non-circulating T cells that are the most important in protecting against infection. In this application we propose to show that only a subset of T cells can form the resident population and to identify the molecules that determine T cell residency. This information can then be used for the efficient construction of disease preventing vaccines.

免疫依赖于被称为T细胞的白血球，这种白血球在身体周围循环，也被发现永久滞留在身体表面。在预防感染方面，非循环T细胞是最重要的。在这个应用中，我们建议证明只有T细胞的子集可以形成常驻群体，并识别决定T细胞驻留的分子。然后，这些信息可用于有效构建疾病预防疫苗。