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Defining the role of CDK6 and DNA repair pathways in tumorigenesis and identify CDK4/6-dependent synthetic lethal vulnerabilities in triple negative breast cancer.

Defining the role of CDK6 and DNA repair pathways in tumorigenesis and identify CDK4/6-dependent synthetic lethal vulnerabilities in triple negative breast cancer.
定义 CDK6 和 DNA 修复途径在肿瘤发生中的作用，并确定三阴性乳腺癌中依赖于 CDK4/6 的合成致死漏洞。
批准号：
455857
负责人：
Lebrun Jean-Jacques
金额：
$7.29万
依托单位：
McGill University Health Centre
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2021
资助国家：
加拿大
项目状态：
已结题
起止时间：
2021-09-01 至 2022-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=455857&lang=en
关键词：
Cdk4/6 Kinase Inhibitors Combination Therapy Crispr Genome-Wide Screen Customized "Druggable Target" Crispr Library Dna Repair Nhej Inhibitors Parp Inhibitors Preclinical Models Of Breast Cancer Synthetic Lethality Triple Negative Breast Cancer

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中文摘要
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英文摘要
Metastatic cancers are the most aggressive cancers, accounting for 90% of all cancer-related deaths. Radiation as well as chemotherapy are not effective enough to fight against these types of cancers. Our lab is studying triple-negative breast cancers (TN
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Exploiting a novel dual-specificity cell cycle inhibitor, KP108 as a therapeutic approach for metastatic breast cancer
  • 批准号：
    469188
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    Operating Grants
  • 资助金额：
    $88.89万
  • 财政年份：
    2022
  • 负责人：
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  • 依托单位：
    McGill University Health Centre
Defining the role of CDK6 and DNA repair pathways in tumorigenesis and identify CDK4/6-dependent synthetic lethal vulnerabilities in triple negative breast cancer.
  • 批准号：
    461405
  • 项目类别：
    Operating Grants
  • 资助金额：
    $76.24万
  • 财政年份：
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  • 负责人：
    Lebrun Jean-Jacques
  • 依托单位：
    McGill University Health Centre
Characterization of the TGFß microRNAome - implications for new biomarkers and therapeutic targets in human cancer
CDK4 regulation of breast cancer stem cells - A novel prognostic marker and therapeutic target for triple-negative breast cancer and chemotherapy-resistant tumors.
  • 批准号：
    345984
  • 项目类别：
    Operating Grants
  • 资助金额：
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  • 财政年份：
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  • 负责人：
    Lebrun Jean-Jacques
  • 依托单位：
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