A systems-biology approach to understanding the beneficial heterologous effects of neonatal BCG vaccination in a Melbourne-based randomised controlled trial

在墨尔本的一项随机对照试验中，采用系统生物学方法来了解新生儿 BCG 疫苗接种的有益异源效应

• 批准号: nhmrc : 1099680
• 负责人: A/Pr Katie Flanagan
• 金额: $ 57.7万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/systems-biology-approach-controlled-trial/662467
• 关键词: systems; biology; approach; understanding; beneficial

BCG vaccine (usually used to protect against TB) also enhances the immune system of young babies to protect them against infections other than TB. We have a large collection of blood samples from a study in which babies were randomised to be given BCG vaccine at birth or no BCG. We will use these to understand the immunological and molecular mechanisms by which BCG boosts the immune system to protect against infections other than TB.

BCG疫苗（通常用于预防结核病）还可以增强婴儿的免疫系统，保护他们免受结核病以外的感染。我们从一项研究中收集了大量的血液样本，在这项研究中，婴儿被随机分配到出生时接种BCG疫苗或不接种BCG。我们将利用这些来了解BCG增强免疫系统以防止结核病以外的感染的免疫学和分子机制。