BCG immunisation to prevent allergy in children: an intervention trial

卡介苗免疫预防儿童过敏：一项干预试验

• 批准号: nhmrc : 1051228
• 负责人: A/Pr Katie Flanagan
• 金额: $ 79.17万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/bcg-immunisation-prevent-intervention-trial/112204
• 关键词: BCG; immunisation; prevent; allergy; children

There has been a dramatic rise in allergic diseases (asthma, eczema, food allergy) worldwide and particularly in Australia, with up to 30% of children affected. There is evidence from small studies that BCG immunisation has beneficial effects that prevent an allergic type immune response later in life. In a large randomised trial we will determine whether BCG at birth prevents allergic disease by monitoring eczema and food sensitivity in infancy, both of which predict an allergic predisposition.

过敏性疾病（哮喘，湿疹，食物过敏）在全球范围内急剧上升，特别是在澳大利亚，高达30%的儿童受到影响。有证据表明，从小的研究表明，卡介苗免疫接种有有益的影响，防止过敏型免疫反应在以后的生活。在一项大型随机试验中，我们将通过监测婴儿期湿疹和食物敏感性来确定出生时BCG是否能预防过敏性疾病，这两种因素都能预测过敏倾向。