Targeting Eph receptors as anti-cancer therapy in malignant glioma.

恶性胶质瘤是脑癌最常见的形式，其特点是发病率和死亡率都很高。目前的治疗包括手术和辅助放化疗，但尽管有最好的护理，这种疾病的患者前景很差。对神经胶质瘤生物学的日益了解为改进治疗提供了前景。本研究旨在研究人类恶性神经胶质瘤动物模型中该疾病的治疗靶点。

Malignant gliomas are the commonest form of brain cancer and are characterised by a high degree of morbidity and mortality. Present treatment involves surgery and adjuvant chemoradiotherapy but despite best care the outlook for patients with this disease is poor. The increasing understanding of the biology of glioma offers the prospect of improved therapies. This proposal seeks to investigate a therapy target in this disease in animal models of human malignant glioma.