Targeting Eph receptors as anti-cancer therapy in malignant glioma.

靶向 Eph 受体作为恶性神经胶质瘤的抗癌治疗。

• 批准号: nhmrc : 552489
• 负责人: Dr David Walker
• 金额: $ 26.91万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-eph-receptors-malignant-glioma/94674
• 关键词: Targeting; Eph; receptors; anti; cancer

Malignant gliomas are the commonest form of brain cancer and are characterised by a high degree of morbidity and mortality. Present treatment involves surgery and adjuvant chemoradiotherapy but despite best care the outlook for patients with this disease is poor. The increasing understanding of the biology of glioma offers the prospect of improved therapies. This proposal seeks to investigate a therapy target in this disease in animal models of human malignant glioma.

恶性神经胶质瘤是最常见的脑癌形式，其特征在于高发病率和死亡率。目前的治疗包括手术和辅助放化疗，但尽管有最好的护理，这种疾病的患者的前景是穷人。对胶质瘤生物学的日益了解为改进治疗提供了前景。该建议旨在通过人类恶性胶质瘤的动物模型来研究这种疾病的治疗靶点。