New ligands, reagents and strategies for asymmetric synthesis

不对称合成的新配体、试剂和策略

• 批准号: 93010-2007
• 负责人: Chong, Michael
• 金额: $ 4.41万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=421620
• 关键词: New; ligands; reagents; strategies; asymmetric

The proposed research is aimed at developing new methods for the synthesis of chiral compounds. Since the chirality or handedness of a drug can have a major impact on its biological activity, it is important to make potential drugs either entirely left-handed or right-handed. The focus will be on creating new reagents to carry out transformations which are not currently possible using existing methodology or have significant advantages over existing methodology.

拟议的研究旨在开发合成手性化合物的新方法。由于药物的手性或利手性可能对其生物活性产生重大影响，因此制造完全左旋或右旋的潜在药物是很重要的。重点将是创造新的试剂，以进行目前使用现有方法无法实现的或与现有方法相比具有重大优势的转化。