Targeting Toxoplasma gondii latent stages responsible for chronic disease

针对导致慢性疾病的弓形虫潜伏期

• 批准号: nhmrc : 1046587
• 负责人: Prof Malcolm Mcconville
• 金额: $ 46.48万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-toxoplasma-gondii-chronic-disease/111854
• 关键词: Targeting; Toxoplasma; gondii; latent; stages

Many microbial pathogens become resistant to host immune response and drugs by entering a slow-growing, dormant state. These stages are commonly responsible for long term, chronic infections. We will investigate the molecular basis of dormancy in Toxoplasma gondii, which infects one in three people. These studies will identify metabolic pathways that are essential for dormancy with the view of developing new therapies for treating long term, recurrent infections.

许多微生物病原体通过进入缓慢生长的休眠状态而对宿主免疫反应和药物产生抗性。这些阶段通常是长期慢性感染的原因。我们将研究弓形虫休眠的分子基础，弓形虫感染三分之一的人。这些研究将确定休眠所必需的代谢途径，以期开发治疗长期复发性感染的新疗法。