TEMPERATURE AS MODIFIER OF MAMMALIAN SKELETAL MUSCLE FUNCTION AND OF MUSCLE RESPONSIVENESS TO PHYSIOLOGICAL FACTORS

温度作为哺乳动物骨骼肌功能和肌肉对生理因素反应的调节剂

• 批准号: nhmrc : 148645
• 负责人: Prof D. George Stephenson
• 金额: $ 17.07万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/temperature-modifier-mammalian-physiological-factors/97376
• 关键词: TEMPERATURE; MODIFIER; MAMMALIAN; SKELETAL; MUSCLE

Contracting muscles are a major source of heat production in the body. Heat produced by contracting muscles can cause muscle damage if muscle temperature increases above 44oC. Also, overheating from external sources can cause an increase in muscle temperature in the upper physiological range of temperature (37-44oC) which can so readily happen to humans and animals caught in blistering sun or in closed cars parked in the sun. However, very little is known about what happens to the ability of the skeletal muscle to contract when the temperature increases in this upper physiological range of temperature. This project seeks to fill in this important gap in our knowledge and increase our understanding about the existence of protective mechanisms in muscle to prevent heat-induced damage to the muscle. Such mechanisms would allow the body to operate very close to the lethal range of temperature and may be mainly responsible for the severe muscle weakness in overheated individuals. Results obtained from the project can have far reaching implications for human physiology in general and muscle and exercise physiology in particular and for developing new strategies in the treatment of collapse from body overheating. The project will also produce new knowledge regarding the mechanism of action of drugs used in the treatment of certain mental disorders but which can trigger, in susceptible individuals, uncontrolled contraction of muscles and overheating.

收缩肌肉是体内热量产生的主要来源。如果肌肉温度升高到44oC以上，则通过收缩肌肉产生的热量会造成肌肉损伤。同样，外部来源过热可能会导致肌肉温度的升高（37-44oc），这很容易发生在人类和动物中，被散发出的阳光或停放在阳光下的封闭汽车中。但是，对于温度上升的温度升高时，骨骼肌肉收缩的能力会发生什么，几乎没有什么了解。该项目试图在我们的知识中填补这一重要差距，并提高我们对肌肉保护性机制存在的理解，以防止热诱导肌肉的损害。这种机制将使人体非常接近致命的温度范围，并可能主要导致过热个体中严重的肌肉无力。从该项目获得的结果可能对人类生理学具有很大的影响，尤其是肌肉，尤其是运动生理学，以及制定新的策略来治疗人体过热的崩溃。该项目还将产生有关用于治疗某些精神疾病的药物作用机理的新知识，但可以触发敏感的个体，肌肉的收缩不受控制和过热。