Mechanisms regulating excitation-contraction coupling in skeletal muscle

骨骼肌兴奋-收缩耦合的调节机制

• 批准号: nhmrc : 280623
• 负责人: Prof D. George Stephenson
• 金额: $ 45.86万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-regulating-excitation-skeletal-muscle/95104
• 关键词: Mechanisms; regulating; excitation; contraction; coupling

Muscle contraction occurs when an electrical impulse from a nerve travels over the surface of a skeletal muscle fibre and triggers the release of calcium ions from special stores inside the fibre. However, little is known about the regulatory mechanisms involved in turning on and turning off the calcium release. This project investigates the properties of the calcium release and what processes are involved in regulating it. Information about this is vital for understanding how normal muscle works and why muscles show reduced performance with exercise (muscle fatigue), with aging, and in certain diseases.

当来自骨骼肌纤维的表面上的电脉冲传播并触发钙离子从纤维内部的特殊商店释放时，就会发生肌肉收缩。但是，对于打开和关闭钙释放所涉及的调节机制知之甚少。该项目调查了钙释放的特性以及调节它的哪些过程。有关此信息的信息对于了解正常肌肉的工作方式以及肌肉的表现（肌肉疲劳），衰老和某些疾病的表现至关重要。