Excitation-contraction coupling in skeletal muscle in health, exercise and disease

健康、运动和疾病中骨骼肌的兴奋-收缩耦合

• 批准号: nhmrc : 541938
• 负责人: Prof D. George Stephenson
• 金额: $ 41.58万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/excitation-contraction-coupling-exercise-disease/94859
• 关键词: Excitation; contraction; coupling; skeletal; muscle

Skeletal muscle dysfunction occurs in certain diseases, aging and exercise, and can deleteriously affect lifestyle and mobility. This project investigates the molecular mechanisms involved in the complex sequence of events that occur in each individual muscle fibre, starting from stimulation by a nerve through to the fibre contracting. This should give information about causes of skeletal muscle dysfunction in myotonia, heart failure and other situations, and help development of therapies.

骨骼肌功能障碍发生在某些疾病，衰老和运动中，并可能影响生活方式和流动性。该项目研究了每个单个肌肉纤维中发生的复杂事件序列所涉及的分子机制，从神经刺激到纤维收缩。这应该提供有关肌肉骨骼肌肉功能障碍的原因，心力衰竭和其他情况，并有助于疗法的发展。