A temporal profile of signaling via phosphorylation during myocardial ischemia - reperfusion injury

心肌缺血-再灌注损伤期间磷酸化信号传导的时间分布

• 批准号: nhmrc : 571002
• 负责人: A/Pr Brett Hambly
• 金额: $ 24.65万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/temporal-profile-signaling-reperfusion-injury/77166
• 关键词: temporal; profile; signaling; via; phosphorylation

Cardiovascular disease (CVD) is the major cause of death in Australians and sequelae post-myocardial ischemia - reperfusion (I-R) are responsible for the greatest proportion of CVD-related mortality. Despite this burden, there is little known of the molecular events that mediate I-R. This project will utilize cutting-edge technology to elucidate the molecular signaling events that lead to I-R injury, as well as determine the basis for protection afforded by clinical pre- and post-conditioning.

心血管疾病 (CVD) 是澳大利亚人死亡的主要原因，而心肌缺血再灌注 (I-R) 后遗症在 CVD 相关死亡率中所占比例最大。尽管有这样的负担，但我们对介导 I-R 的分子事件知之甚少。该项目将利用尖端技术来阐明导致 I-R 损伤的分子信号事件，并确定临床预处理和后处理提供保护的基础。