Therapeutic potential of inhibiting Eph/ephrin signalling to repair the vascular endothelium in septic shock

抑制 Eph/ephrin 信号传导修复感染性休克血管内皮的治疗潜力

• 批准号: nhmrc : GNT1142995
• 负责人: A/Pr Mark Coulthard
• 金额: $ 66.47万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/therapeutic-potential-inhibiting-septic-shock/1348494
• 关键词: Therapeutic; potential; inhibiting; Eph; ephrin

Septic shock is a life-threatening condition usually caused by bacterial infection in the bloodstream. More than 5000 people, including 500 children, die from sepsis each year in Australia. Worldwide, it is the most significant cause of death in children. Sepsis is associated with leakage of fluid and proteins through the cells lining the blood vessels. This project will develop and test a novel treatment for sepsis which focuses on reducing this leakage by blocking the Eph/ephrin proteins.

感染性休克是一种危及生命的疾病，通常由血液中的细菌感染引起。在澳大利亚，每年有超过5000人，包括500名儿童，死于败血症。在世界范围内，它是儿童死亡的最重要原因。脓毒症与液体和蛋白质通过血管内衬细胞的渗漏有关。该项目将开发和测试一种新的败血症治疗方法，其重点是通过阻断Eph/ephrin蛋白来减少这种泄漏。