TRACEBACK - identification of women carrying germline BRCA1/2 mutations through a retrospective analysis of patients diagnosed with high grade serous ovarian cancer.

TRACEBACK - 通过对诊断为高级别浆液性卵巢癌的患者进行回顾性分析，识别携带种系 BRCA1/2 突变的女性。

• 批准号: nhmrc : GNT1133906
• 负责人: Dr Rachel Delahunty
• 金额: $ 8.33万
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/traceback-identification-women-ovarian-cancer/1347924
• 关键词: TRACEBACK; identification; women; carrying; germline

Inheriting a mutated-BRCA is associated with significant risk of developing cancer. It is a crucial diagnosis to make with proven procedures that can reduce the risk of cancer developing. Ovarian cancer (HGSOC) is the tumour most strongly associated with BRCA (15-20%) and provides a diagnostic opportunity, but despite Australian guidelines <50% receive testing. Our aim is to provide BRCA1/2 screening opportunities to patients and families and improve the rate of BRCA testing Australia wide.

遗传突变的brca与患癌症的风险显著相关。这是一个关键的诊断，需要经过验证的程序，可以降低癌症发展的风险。卵巢癌（HGSOC）是与BRCA最密切相关的肿瘤（15-20%），并提供了诊断机会，但尽管澳大利亚的指导方针&lt；50%接受检测。我们的目标是为患者和家属提供BRCA1/2筛查机会，并提高澳大利亚范围内BRCA检测的率。