Transcriptional control of megakaryopoiesis

血液凝结依赖于血小板。血小板数量下降，或称血小板减少，是一种危及生命的疾病，可由各种疾病引起，或者更重要的是，是化疗的副作用。我们正在研究控制血小板生成的方法。一个长期的目标是通过促进自然途径来刺激患者的血小板生成，或者通过基因重新编程从患者自己的皮肤细胞中产生用于输血的血小板生成细胞。

Blood clotting is dependent upon platelets. A decline in platelet number, or thrombocytopenia, is a life threatening condition that can result from various diseases or importantly as a side effect of chemotherapy. We are investigating the control of platelet production. A long term goal is to stimulate platelet production in patients by boosting the natural pathways or to generate platelet producing cells for transfusion from a patient's own skin cells by genetic reprogramming.