Are Proteostasis defects responsible for Amyotrophic Lateral Sclerosis?

蛋白质稳态缺陷是否导致肌萎缩侧索硬化症？

• 批准号: DE120102840
• 负责人: Dr Justin Yerbury
• 金额: $ 26.91万
• 依托单位: University of Wollongong
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-06-30 至 2015-06-29
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE120102840
• 关键词: Proteostasis; defects; responsible; Amyotrophic; Lateral

Currently the cause of motor neurone disease (MND) is a mystery. There is, however, a growing group of unrelated genes associated with inherited MND. This project aims to show that this group of apparently diverse genes all contribute to a single cellular function called protein homeostasis and that mutations in these genes cause homeostasis disruptions.

目前运动神经元病(MND)的病因仍是个谜。然而，越来越多的无关基因与遗传性MND有关。该项目旨在表明，这组明显不同的基因都有助于实现一种称为蛋白质稳态的单一细胞功能，而这些基因的突变会导致稳态的破坏。