Transfer of glutamine between astrocytes and neurons

星形胶质细胞和神经元之间谷氨酰胺的转移

• 批准号: nhmrc : 224229
• 负责人: Prof Stefan Broer
• 金额: $ 17.04万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/transfer-glutamine-astrocytes-neurons/100008
• 关键词: Transfer; glutamine; between; astrocytes; neurons

Brain tissue is comprised of only a few different cell types. These are classified as neurons, glial cells, and cells of mesodermal origin. Glial cells are the most abundant cell type in the brain and include cells known as astrocytes. There is increasing evidence that astrocytes are actively involved in the maintenance and regulation of neuronal function. This study focuses on the mechanisms by which astrocytes supply neurons with precursors for the formation of signalling molecules (neurotransmitters) released from neurons in the transmission of nerve impulses. It will establish how these processes are controlled and also try to develop inhibitors that interfere with this process . The project tries to elucidate whether astrocytes actively regulate neuronal functions by regulating precursor supply. The work will make a significant contribution to our understanding of how astrocytes regulate neuronal activity, a process that may be critical in conditions such as stroke and epilepsy. A better understanding of the physiology of astrocytes might lead to improved treatments for these disturbances of brain function.

脑组织只由几种不同类型的细胞组成。这些细胞可分为神经元细胞、胶质细胞和中胚层细胞。神经胶质细胞是大脑中最丰富的细胞类型，包括星形胶质细胞。越来越多的证据表明星形胶质细胞积极参与神经元功能的维持和调节。本研究主要探讨星形胶质细胞为神经冲动传递过程中神经元释放的信号分子（神经递质）的形成提供前体的机制。它将确定这些过程是如何被控制的，并试图开发出干扰这一过程的抑制剂。该项目试图阐明星形胶质细胞是否通过调节前体供应来积极调节神经元功能。这项工作将对我们理解星形胶质细胞如何调节神经元活动做出重大贡献，这一过程可能对中风和癫痫等疾病至关重要。更好地了解星形胶质细胞的生理学可能会导致改善这些脑功能紊乱的治疗方法。