Transfer of glutamine between astrocytes and neurons

脑组织仅由几种不同的细胞类型组成。这些被分类为神经元、神经胶质细胞和中胚层起源的细胞。神经胶质细胞是大脑中最丰富的细胞类型，包括称为星形胶质细胞的细胞。越来越多的证据表明星形胶质细胞积极参与神经元功能的维持和调节。本研究的重点是星形胶质细胞供应神经元的前体形成的信号分子（神经递质）的神经冲动的传输中释放的神经元的机制。它将确定如何控制这些过程，并试图开发干扰这一过程的抑制剂。该项目试图阐明星形胶质细胞是否通过调节前体供应来积极调节神经元功能。这项工作将为我们理解星形胶质细胞如何调节神经元活动做出重大贡献，这一过程在中风和癫痫等疾病中可能至关重要。更好地了解星形胶质细胞的生理学可能会导致改善这些脑功能障碍的治疗方法。

Brain tissue is comprised of only a few different cell types. These are classified as neurons, glial cells, and cells of mesodermal origin. Glial cells are the most abundant cell type in the brain and include cells known as astrocytes. There is increasing evidence that astrocytes are actively involved in the maintenance and regulation of neuronal function. This study focuses on the mechanisms by which astrocytes supply neurons with precursors for the formation of signalling molecules (neurotransmitters) released from neurons in the transmission of nerve impulses. It will establish how these processes are controlled and also try to develop inhibitors that interfere with this process . The project tries to elucidate whether astrocytes actively regulate neuronal functions by regulating precursor supply. The work will make a significant contribution to our understanding of how astrocytes regulate neuronal activity, a process that may be critical in conditions such as stroke and epilepsy. A better understanding of the physiology of astrocytes might lead to improved treatments for these disturbances of brain function.