A unified model of amino acid homeostasis

氨基酸稳态的统一模型

• 批准号: DP180101702
• 负责人: Prof Stefan Broer
• 金额: $ 30.04万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-05-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180101702
• 关键词: unified; model; amino; acid; homeostasis

This project aims to develop a unified model of amino acid homeostasis in mammalian cells and apply it to brain cells. The model will be underpinned by a mathematical algorithm that allows predicting amino acid levels in the cytosol based on fundamental parameters such as transport and metabolism. This project should provide the significant benefit of enabling the prediction of essential functions such as cell growth and survival.

该项目旨在开发哺乳动物细胞中氨基酸动态平衡的统一模型，并将其应用于脑细胞。该模型将以一种数学算法为基础，该算法可以根据运输和新陈代谢等基本参数预测细胞质中的氨基酸水平。这个项目应该能够提供重要的益处，能够预测细胞的生长和存活等基本功能。