Conductance states of a brain glutamine transporter

脑谷氨酰胺转运蛋白的电导状态

• 批准号: LX0881952
• 负责人: Prof Stefan Broer
• 金额: $ 1.73万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage - International
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LX0881952
• 关键词: Conductance; states; brain; glutamine; transporter

Brain transporters are the target for many neuroactive drugs that are used to treat anxiety, depression and other psychotic disorders. Transport processes are also targeted to deliver neurotransmitter precursors to the brain to treat disorders such as Parkinson's disease. In this project we will study a transport process crucial for the function of neurons that release glutamate and GABA (gamma-aminobutyric acid) as neurotransmitters. The study of this transport process will be important for understanding disorders like epilepsy and other disorders affecting neuronal excitability.

大脑转运体是许多神经活性药物的靶点，这些药物被用来治疗焦虑、抑郁和其他精神障碍。转运过程也有针对性地将神经递质前体输送到大脑，以治疗帕金森氏症等疾病。在这个项目中，我们将研究对释放谷氨酸和GABA(伽马氨基丁酸)作为神经递质的神经元的功能至关重要的运输过程。对这一转运过程的研究将对理解癫痫等疾病和其他影响神经元兴奋性的疾病具有重要意义。