Neurobiological basis of the supraspinal regulation of nociception

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One of the most remarkable findings in pain research is the discovery that the brain can alter the sensitivity to noxious stimuli in the periphery. This explains how various psychological states can alter nociceptive thresholds and ultimately, the pain experience itself. For example, the same noxious stimulus can provoke different responses when experienced under different emotional conditions. It is now well documented that anxiety or stress can amplify the physical sensation of pain, sensitize nociceptive pathways and thereby, contribute to the development of pathophysiological pain states.