Development of a Lab-on-a-Chip solution for detection of Diarrhoea Viruses: A nanotechnology empowered microdevice

开发用于检测腹泻病毒的芯片实验室解决方案：纳米技术支持的微型设备

• 批准号: 350739-2007
• 负责人: Yeow, TzeWei(John)
• 金额: $ 9.23万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Strategic Projects - Group
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=431312
• 关键词: Development; Lab; Chip; solution; detection

The development of bioinformatics databases has led to the demand for analytical systems capable of handling very small samples but still being able to provide information on specific biomolecules contained within the samples. During the past decade, processing of biological samples for these purposes is automated, at a small-scale, and high-throughput operation with lower cost but without compromise in accuracy. The ability to miniaturize biomedical devices to the order of micrometers has created a new paradigm based on which drug development, biotechnology development, genetic analysis, and clinical diagnosis and treatment are performed The development of Lab-on-a-Chip devices using microelectromechaical systems (MEMS) and nanotechnology has enabled the miniaturization and integration of multiple molecular diagnostic systems. The proposed project will focus on the development of a Lab-on-a-Chip device to perform multiple functions, such as on-chip cell separation, cell lysis, biomolecular separation and real-time PCR. The developed devices or subsystems are envisioned to be integrated within water and waste treatment facilities for real-time monitoring of pathogens.

生物信息学数据库的发展导致了对分析系统的需求，该分析系统能够处理非常小的样品，但仍然能够提供关于样品中包含的特定生物分子的信息。在过去的十年中，用于这些目的的生物样本处理是自动化的，小规模、高通量操作，成本较低，但准确性不受影响。将生物医学设备微尺寸化到微米量级的能力已经创造了一种新的范例，基于该范例进行药物开发、生物技术开发、遗传分析以及临床诊断和治疗。使用微机电系统（MEMS）和纳米技术的芯片实验室设备的开发已经使得多个分子诊断系统的小型化和集成成为可能。拟议项目将专注于开发一种芯片实验室设备，以执行多种功能，例如芯片细胞分离，细胞裂解，生物分子分离和实时PCR。所开发的设备或子系统被设想集成在水和废物处理设施内，用于实时监测病原体。