Metal colloids showing high signal and enhanced contrast in cellular and molecular imaging with MRI and PET/MRI

金属胶体在 MRI 和 PET/MRI 的细胞和分子成像中显示出高信号和增强的对比度

基本信息

  • 批准号:
    355524-2008
  • 负责人:
  • 金额:
    $ 2.03万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2009
  • 资助国家:
    加拿大
  • 起止时间:
    2009-01-01 至 2010-12-31
  • 项目状态:
    已结题

项目摘要

Molecular imaging allows modern medicine to examine the functions of molecules and cells in living organisms. Diseases such as cancer, atherosclerosis and Alzheimer, can now be detected precisely and non-invasively at a much earlier stage. Imaging scanners have reached a high level of development and henceforth intense efforts are being invested in the development of biomarkers with improved properties. This research program addresses a crucial aspect of molecular imaging: the development of contrast agents and tracers (biomarkers) providing high and specific signal in magnetic resonance imaging (MRI) and positron emission tomography (PET). In fact, a next generation of scanners combining MRI and PET will soon become a reality in the clinic. MRI is a non-invasive imaging technique providing high resolution pictures in low density tissues. Magnetic molecules or nanoparticles are often necessary to finely delineate the vasculature, to precisely identify disease artefacts, and to track cells. The rather poor sensibility per unit of biomarker is the major limitation of MRI, which requires the use of large amounts of magnetic metals in-vivo. PET is also a non-invasive imaging technique, based on the detection of radioactive tracers at very high sensitivity. This method requires very small quantities of radioactive atoms; the resolution however remains lower than with MRI. At present, both imaging techniques (MRI and PET) can be used separately for studying physiological features and molecular targets. Could we perform both MRI and PET at the same time? Magnetic metal colloids in the form of nanoparticles, can be used to improve the specificity of the MRI signal. By doping these crystalline "nanomaterials" with carefully selected radioactive atoms, a next generation of biomarkers could become available for dual PET/MRI procedures. This research program focuses on the synthesis, characterization and signal study of dual contrast agents produced in the form of magnetoradioactive colloids. In the long term, such colloids could be used as molecular tags, as cell markers, and also as enhancers of MRI contrast for biomedical devices.
分子成像使现代医学能够检查活生物体中分子和细胞的功能。癌症、动脉粥样硬化和阿尔茨海默病等疾病现在可以在更早的阶段进行精确和非侵入性的检测。成像扫描仪已经达到了很高的发展水平,因此人们正在投入大量精力开发具有改进性能的生物标志物。这个研究项目解决了分子成像的一个关键方面:在磁共振成像(MRI)和正电子发射断层扫描(PET)中提供高特异性信号的造影剂和示踪剂(生物标志物)的发展。事实上,结合核磁共振和PET的下一代扫描仪将很快在临床上成为现实。MRI是一种无创成像技术,可在低密度组织中提供高分辨率图像。磁性分子或纳米颗粒通常是精细描绘脉管系统、精确识别疾病伪影和跟踪细胞所必需的。每单位生物标志物相当差的敏感性是MRI的主要限制,这需要在体内使用大量的磁性金属。PET也是一种非侵入性成像技术,基于非常高灵敏度的放射性示踪剂检测。这种方法只需要非常少量的放射性原子;但分辨率仍低于MRI。目前,两种成像技术(MRI和PET)都可以单独用于研究生理特征和分子靶点。我们可以同时做MRI和PET吗?磁性金属胶体以纳米颗粒的形式存在,可用于提高MRI信号的特异性。通过将这些晶体“纳米材料”与精心挑选的放射性原子掺杂,下一代生物标志物可以用于PET/MRI双重程序。本研究项目的重点是合成、表征和信号研究的双重造影剂生产形式的磁放射性胶体。从长远来看,这种胶体可以用作分子标签、细胞标记,也可以用作生物医学设备的MRI对比增强剂。

项目成果

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Fortin, MarcAndré其他文献

Fortin, MarcAndré的其他文献

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{{ truncateString('Fortin, MarcAndré', 18)}}的其他基金

Cryo-TEM infrastructure for the visualisation of nanoparticles, exosomes, and virus-like particles
用于纳米颗粒、外泌体和病毒样颗粒可视化的冷冻 TEM 基础设施
  • 批准号:
    RTI-2023-00202
  • 财政年份:
    2022
  • 资助金额:
    $ 2.03万
  • 项目类别:
    Research Tools and Instruments
Nanostructured biomaterials for contrast enhancement in imaging
用于增强成像对比度的纳米结构生物材料
  • 批准号:
    RGPIN-2017-06173
  • 财政年份:
    2021
  • 资助金额:
    $ 2.03万
  • 项目类别:
    Discovery Grants Program - Individual
Nanostructured biomaterials for contrast enhancement in imaging
用于增强成像对比度的纳米结构生物材料
  • 批准号:
    RGPIN-2017-06173
  • 财政年份:
    2020
  • 资助金额:
    $ 2.03万
  • 项目类别:
    Discovery Grants Program - Individual
Gold nanoparticles as additives in polyether ether ketone (PEEK) filaments used in 3D printing
金纳米颗粒作为 3D 打印用聚醚醚酮 (PEEK) 长丝的添加剂
  • 批准号:
    539942-2019
  • 财政年份:
    2019
  • 资助金额:
    $ 2.03万
  • 项目类别:
    Engage Grants Program
Nanostructured biomaterials for contrast enhancement in imaging
用于增强成像对比度的纳米结构生物材料
  • 批准号:
    RGPIN-2017-06173
  • 财政年份:
    2019
  • 资助金额:
    $ 2.03万
  • 项目类别:
    Discovery Grants Program - Individual
Nanostructured biomaterials for contrast enhancement in imaging
用于增强成像对比度的纳米结构生物材料
  • 批准号:
    RGPIN-2017-06173
  • 财政年份:
    2018
  • 资助金额:
    $ 2.03万
  • 项目类别:
    Discovery Grants Program - Individual
Laboratory for Additive Manufacturing (3D Printing) of Biomedical Polymers
生物医用聚合物增材制造(3D打印)实验室
  • 批准号:
    RTI-2018-00793
  • 财政年份:
    2017
  • 资助金额:
    $ 2.03万
  • 项目类别:
    Research Tools and Instruments
Quantitative biodistribution of viral nanoparticles by nuclear imaging
通过核成像定量病毒纳米粒子的生物分布
  • 批准号:
    509485-2017
  • 财政年份:
    2017
  • 资助金额:
    $ 2.03万
  • 项目类别:
    Engage Grants Program
Nanostructured biomaterials for contrast enhancement in imaging
用于增强成像对比度的纳米结构生物材料
  • 批准号:
    RGPIN-2017-06173
  • 财政年份:
    2017
  • 资助金额:
    $ 2.03万
  • 项目类别:
    Discovery Grants Program - Individual
Imaging tracers for cell tracking applications with magnetic resonance imaging (MRI) and positron emission tomography (PET)
用于磁共振成像 (MRI) 和正电子发射断层扫描 (PET) 细胞追踪应用的成像示踪剂
  • 批准号:
    355524-2012
  • 财政年份:
    2016
  • 资助金额:
    $ 2.03万
  • 项目类别:
    Discovery Grants Program - Individual

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  • 批准号:
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    2024
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Observation of multiple optical phenomena using a single wavelength: Prediction of coagulation of colloids by simultaneous measurement of light scattering and fluorescence
使用单一波长观察多种光学现象:通过同时测量光散射和荧光来预测胶体的凝固
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用于光遗传学神经调节的机械发光纳米材料
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