Thyroid hormone influence on gonadal function and development: an amphibian model

甲状腺激素对性腺功能和发育的影响：两栖动物模型

• 批准号: 358787-2009
• 负责人: Hogan(Gallant), Natacha
• 金额: $ 1.75万
• 依托单位: University of Prince Edward Island
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=432527
• 关键词: Thyroid; hormone; influence; gonadal; function

There has been an increasing awareness of contaminants in the aquatic environment and evidence for their capacity to affect organisms through the disruption of the natural action of hormones. Although hormonal systems are often studied in isolation, they do not work in isolation, but instead interact at several levels to regulate development and reproduction in an organism. Our ability to predict the risk that contaminants pose to amphibians (and other animals) is currently limited by lack of knowledge as to how different hormonal systems work together. Thus, it is imperative that we understand how hormone systems interact in order to accurately predict the impact of these contaminants on animal health. This research will address knowledge gaps in the interaction of thyroid hormone and reproductive hormone systems. This research will explore the relationship between the amphibian thyroidal- and reproductive-endocrine systems by examining their interactions within the context of a specific reproductive function: hormone production in the gonad. We will also use the process of metamorphosis to examine how these interactions are influenced by developmental changes in endocrine status. This research has the potential to provide important new ideas about thyroidal involvement in reproduction and will allow us to study how changes in thyroid status, either in development or as a result of contaminant exposure, can influence reproduction.

人们越来越意识到水环境中的污染物，并有证据表明它们有能力通过破坏荷尔蒙的自然作用来影响生物体。虽然荷尔蒙系统经常被孤立地研究，但它们并不是孤立地工作，而是在几个水平上相互作用，以调节有机体的发育和繁殖。我们预测污染物对两栖动物(和其他动物)造成的风险的能力目前受到缺乏关于不同荷尔蒙系统如何协同工作的知识的限制。因此，为了准确预测这些污染物对动物健康的影响，我们必须了解激素系统是如何相互作用的。这项研究将解决甲状腺激素和生殖激素系统相互作用方面的知识空白。这项研究将通过研究两栖动物甲状腺内分泌系统和生殖内分泌系统在特定生殖功能：性腺中的激素产生的背景下的相互作用来探索两者之间的关系。我们还将使用变态过程来研究内分泌状态的发育变化如何影响这些相互作用。这项研究有可能为甲状腺参与生殖提供重要的新观点，并将使我们能够研究甲状腺状态的变化，无论是发育中的变化还是污染物暴露的结果，都会影响生殖。