Understanding dendritic cell dysfunction and apoptosis in malaria in endemic populations

了解疟疾流行人群中的树突状细胞功能障碍和细胞凋亡

• 批准号: nhmrc : 1021198
• 负责人: Dr Tonia Woodberry
• 金额: $ 32.89万
• 依托单位: Menzies School of Health Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-dendritic-cell-endemic-populations/110098
• 关键词: Understanding; dendritic; cell; dysfunction; apoptosis

The Asia-Pacific has 40% of the global malaria burden, and both major malaria species (falciparum & vivax) cause disease and death. To eliminate malaria we need to understand how malaria parasites prevent our body making new immune responses. Our experienced team will measure how and when the two major malaria parasites switch off and kill specialised immune cells, when immune cells recover after antimalarial therapy and may suggest the need for malaria drugs to be given before immunisations.

亚太地区占全球疟疾负担的40%，两种主要疟疾（恶性疟和间日疟）都会导致疾病和死亡。为了消除疟疾，我们需要了解疟疾寄生虫如何阻止我们的身体产生新的免疫反应。我们经验丰富的团队将测量两种主要的疟疾寄生虫如何以及何时关闭并杀死专门的免疫细胞，免疫细胞在抗疟疾治疗后何时恢复，并可能建议在免疫接种之前给予疟疾药物。