Understanding the Molecular Basis of Epididymal Maturation: How Does the Epididymis Modify Spermatozoa, Allowing them to Recognise the Egg ?

了解附睾成熟的分子基础：附睾如何改变精子，让它们识别卵子？

• 批准号: nhmrc : 1010753
• 负责人: A/Pr Mark Baker
• 金额: $ 39.07万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-molecular-basis-recognise-egg/109526
• 关键词: Understanding; Molecular; Basis; Epididymal; Maturation

Male infertility is a significant clinical problem affecting one in twenty Australian men. A common feature of this condition is the sperm’s inability to recognize the egg. Sperm gain this property as they transit an organ known as the epididymis. We have produced genetically modified mice with a specific epididymal defect that prevents sperm-egg recognition. This study will examine the structure of these defective sperm to generate new insights into the molecular basis of sperm-egg interaction.

男性不育症是一个严重的临床问题，影响着二十分之一的澳大利亚男性。这种情况的一个共同特征是精子无法识别卵子。精子在通过附睾器官时获得了这种特性。我们培育出了带有特定附睾缺陷的转基因小鼠，这种缺陷会阻止精卵识别。这项研究将检查这些有缺陷的精子的结构，以对精卵相互作用的分子基础产生新的见解。