Understanding sperm motility for infertility and contraceptive purposes

了解精子活力以达到不孕不育和避孕目的

• 批准号: nhmrc : 1029144
• 负责人: A/Pr Mark Baker
• 金额: $ 30.12万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-sperm-motility-contraceptive-purposes/110672
• 关键词: Understanding; sperm; motility; infertility; contraceptive

Male infertility is a significant clinical problem affecting one in twenty Australian men. The most common feature associated with this condition is defects in sperm motility. Regulation of sperm motility occurs through the epididymis and upon ejaculation. This study will examine how two kinases, essential for flagella bending, regulate sperm motility. Through the tools developed, we will investigate further defectives in infertile individuals with impaired sperm motility.

男性不育症是一个严重的临床问题，每20名澳大利亚男性中就有1人患有不育症。与这种情况相关的最常见的特征是精子活力缺陷。精子运动的调节通过附睾和射精发生。本研究将探讨鞭毛弯曲所必需的两种激酶如何调节精子活力。通过开发的工具，我们将进一步研究精子活力受损的不育个体的缺陷。