Identification and characterisation of phosphorylation events taking place during human sperm capacitation

人类精子获能期间发生的磷酸化事件的鉴定和表征

• 批准号: nhmrc : 569258
• 负责人: A/Pr Mark Baker
• 金额: $ 18.7万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-characterisation-phosphorylation-sperm-capacitation/81535
• 关键词: Identification; characterisation; phosphorylation; events; taking

Male infertility affects one in every twenty Australian males and one third of all infertile couples worldwide. The most common cause of human infertility is not a failure to produce sperm, but a failure of these cells to express a normal capacity for fertilization. The cause of this loss of functional competence is unclear. We are going to use our technical expertise in proteomics to characterize the molecular pathways responsible for the defective sperm function seen in infertile patients.

每20名澳大利亚男性中就有1人患有男性不育症，全世界所有不育夫妇中有三分之一患有男性不育症。人类不育最常见的原因不是不能产生精子，而是这些细胞不能表达正常的受精能力。这种功能丧失的原因尚不清楚。我们将利用我们在蛋白质组学方面的技术专长来描述不育患者中精子功能缺陷的分子途径。