Characterising a newly identified mechanism causing elevation of intracranial pressure after acute neurological injury

我们的研究小组发现，脑压力增加（颅内压- ICP）可能比中风和其他潜在的脑部疾病更常见和重要。我们还发现了一种简单的潜在疗法，短时间的身体降温，可以完全防止压力上升。在这个项目中，我们将描述ICP上升的特征，确定其分子触发因素，并确定用于中风患者临床试验的最佳身体冷却方法。

Our group discovered that increased pressure on the brain (intracranial pressure – ICP) may be more common and important than has been recognised following stroke, and potentially other brain disorders. We also identified a simple potential therapy, short-duration body cooling, which completely prevents the pressure rise. In this project we will characterise the ICP rise, identify its molecular trigger and determine the best method of body cooling tor use in clinical trials in stroke patients.