Characterising a newly identified mechanism causing elevation of intracranial pressure after acute neurological injury

表征急性神经损伤后导致颅内压升高的新发现机制

• 批准号: nhmrc : 1085450
• 负责人: A/Pr Mark Baker
• 金额: $ 34.07万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/characterising-newly-identified-neurological-injury/519087
• 关键词: Characterising; newly; identified; mechanism; causing

Our group discovered that increased pressure on the brain (intracranial pressure – ICP) may be more common and important than has been recognised following stroke, and potentially other brain disorders. We also identified a simple potential therapy, short-duration body cooling, which completely prevents the pressure rise. In this project we will characterise the ICP rise, identify its molecular trigger and determine the best method of body cooling tor use in clinical trials in stroke patients.

我们的研究小组发现，脑压增加（颅内压- ICP）可能比中风后认识到的更常见和重要，可能是其他脑部疾病。我们还确定了一种简单的潜在治疗方法，即短时间的身体冷却，它可以完全防止压力上升。在这个项目中，我们将研究颅内压升高，确定其分子触发因素，并确定用于中风患者临床试验的最佳身体冷却方法。