Understanding the shared determinants and causal pathways of early life infection, inflammation and atherosclerosis.

了解生命早期感染、炎症和动脉粥样硬化的共同决定因素和因果途径。

• 批准号: nhmrc : 1064629
• 负责人: Prof David Burgner
• 金额: $ 42.2万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-shared-determinants-inflammation-atherosclerosis/455130
• 关键词: Understanding; shared; determinants; causal; pathways

Infection is the commonest reason for childhood hospitalisation, but it is unknown why infection is much more severe in some children. The long-term effects of infection on the development of atherosclerosis (hardening of the arteries), the underlying cause of cardiovascular disease, is also unknown. This research investigates these important questions with the aim of developing better prediction and prevention of severe infection and reducing its impact on adult cardiovascular disease.

感染是儿童住院的最常见原因，但尚不清楚为什么感染在某些儿童中更为严重。感染对动脉粥样硬化（动脉硬化）发展的长期影响也是未知的，动脉粥样硬化是心血管疾病的根本原因。本研究调查了这些重要问题，旨在更好地预测和预防严重感染，并减少其对成人心血管疾病的影响。