Understanding the shared determinants and causal pathways of early life infection, inflammation and atherosclerosis.

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Infection is the commonest reason for childhood hospitalisation, but it is unknown why infection is much more severe in some children. The long-term effects of infection on the development of atherosclerosis (hardening of the arteries), the underlying cause of cardiovascular disease, is also unknown. This research investigates these important questions with the aim of developing better prediction and prevention of severe infection and reducing its impact on adult cardiovascular disease.