The use of soluble antagonists of EphA4 in spinal cord injuries

可溶性 EphA4 拮抗剂在脊髓损伤中的应用

• 批准号: nhmrc : 511212
• 负责人: A/Pr Ann Turnley
• 金额: $ 41.5万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/use-soluble-antagonists-cord-injuries/77006
• 关键词: use; soluble; antagonists; EphA4; spinal

Permanent and limited recovery of function following spinal cord injury is a direct result of the lack of nerve regrowth through the injury. Our preliminary data suggest that antagonising the effects of EphA4, a protein involved in brain development, leads to substantial functional recovery simultaneous with nerve regrowth. In addition to designing new, more effective blockers of EphA4, we will study the signalling pathways that EphA4 activates to inhibit nerve regrowth.

脊髓损伤后的永久性和有限的功能恢复是损伤中缺乏神经再生的直接结果。我们的初步数据表明，拮抗EphA4（一种参与大脑发育的蛋白质）的作用，可以在神经再生的同时实现实质性的功能恢复。除了设计新的、更有效的EphA4阻滞剂外，我们还将研究EphA4激活抑制神经再生的信号通路。