Enhancement of newborn neuron survival to promote repair following adult brain injury

增强新生神经元存活以促进成人脑损伤后的修复

• 批准号: nhmrc : 1045125
• 负责人: A/Pr Ann Turnley
• 金额: $ 37.06万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/enhancement-newborn-neuron-brain-injury/111716
• 关键词: Enhancement; newborn; neuron; survival; promote

Following brain damage tissue needs to be rebuilt and newborn nerve cells need to survive. Identification of factors that enhance the numbers and promote the survival and appropriate integration of newborn nerve cells is therefore important and over the last few years we have identified two regulatory factors that are prime candidates to enhance numbers and survival of newborn neurons following injury: the Rho pathway and suppressor of cytokine signalling-2, which we will test for effectiveness following brain injury.

脑损伤后，组织需要重建，新生神经细胞需要存活。因此，识别增加新生神经细胞数量并促进其存活和适当整合的因素非常重要，在过去的几年中，我们已经确定了两个调节因子，它们是增强损伤后新生神经元数量和存活的主要候选者：Rho通路和细胞因子信号传导抑制剂-2，我们将测试其在脑损伤后的有效性。