The role of neuronal hyperactivity and neurotrophic factor signalling in synaptogenesis, dendrogenesis and neuron death in motor neuron disease
The role of neuronal hyperactivity and neurotrophic factor signalling in synaptogenesis, dendrogenesis and neuron death in motor neuron disease
批准号:
nhmrc : 1065884
负责人:
A/Pr Ann Turnley
金额:
$46.7万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2016-12-31
中文摘要
点击翻译按钮获取中文摘要
英文摘要
Using mice with mutant genes causing amyotrophic lateral sclerosis, we will test whether motor neuron hyper-excitability during early development causes excessive synapse and dendrite formation, ultimately leading to neuronal death. We will also test whether activity-dependent secretion of neurotrophic factors and activation of their receptors plays a role in this disease. This will show whether neuronal hyper-activity and neurotrophic factor signaling plays a causal role in this disease.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Next generation cybernetics: Long term carbon fibre dual stimulation / recording electrode arrays for closed loop neural implants
-
批准号:nhmrc : 1101717
-
项目类别:Project Grants
-
资助金额:$46.88万
-
财政年份:2016
-
负责人:A/Pr Ann Turnley
-
依托单位:
Novel strategies to promote myelin repair in the brain
-
批准号:nhmrc : GNT1105108
-
项目类别:Project Grants
-
资助金额:$59.79万
-
财政年份:2016
-
负责人:A/Pr Ann Turnley
-
依托单位:
Novel strategies to promote myelin repair in the brain
-
批准号:nhmrc : 1105108
-
项目类别:Project Grants
-
资助金额:$40.98万
-
财政年份:2016
-
负责人:A/Pr Ann Turnley
-
依托单位:
Next generation cybernetics: Long term carbon fibre dual stimulation / recording electrode arrays for closed loop neural implants
-
批准号:nhmrc : GNT1101717
-
项目类别:Project Grants
-
资助金额:$67.97万
-
财政年份:2016
-
负责人:A/Pr Ann Turnley
-
依托单位:
Enhancement of newborn neuron survival to promote repair following adult brain injury
-
批准号:nhmrc : 1045125
-
项目类别:Project Grants
-
资助金额:$37.06万
-
财政年份:2013
-
负责人:A/Pr Ann Turnley
-
依托单位:
Research Fellowship
-
批准号:nhmrc : 628344
-
项目类别:NHMRC Research Fellowships
-
资助金额:$39.41万
-
财政年份:2010
-
负责人:A/Pr Ann Turnley
-
依托单位:
Regulation of astrocytic gliosis and axonal regeneration in EAE by EphA4
-
批准号:nhmrc : 566513
-
项目类别:NHMRC Project Grants
-
资助金额:$35.5万
-
财政年份:2009
-
负责人:A/Pr Ann Turnley
-
依托单位:
The use of soluble antagonists of EphA4 in spinal cord injuries
-
批准号:nhmrc : 511212
-
项目类别:NHMRC Project Grants
-
资助金额:$41.5万
-
财政年份:2008
-
负责人:A/Pr Ann Turnley
-
依托单位:
Role of chemokines and interferons in neural progenitor cell function
-
批准号:nhmrc : 454384
-
项目类别:NHMRC Project Grants
-
资助金额:$34.75万
-
财政年份:2007
-
负责人:A/Pr Ann Turnley
-
依托单位:
Compromised fetal brain development: neurogenesis and the potential for therapeutic intervention.
-
批准号:nhmrc : 454536
-
项目类别:NHMRC Project Grants
-
资助金额:$33.16万
-
财政年份:2007
-
负责人:A/Pr Ann Turnley
-
依托单位:
Is EphA4 the major molecular regulator of axonal regeneration?
-
批准号:nhmrc : 351479
-
项目类别:NHMRC Project Grants
-
资助金额:$32.74万
-
财政年份:2005
-
负责人:A/Pr Ann Turnley
-
依托单位:
Research Fellowship - Grant ID:350226
-
批准号:nhmrc : 350226
-
项目类别:NHMRC Research Fellowships
-
资助金额:$35.89万
-
财政年份:2005
-
负责人:A/Pr Ann Turnley
-
依托单位:
Signalling mechanisms regulating neurogenesis and neurite outgrowth
-
批准号:nhmrc : 350227
-
项目类别:NHMRC Project Grants
-
资助金额:$32.41万
-
财政年份:2005
-
负责人:A/Pr Ann Turnley
-
依托单位:
Suppressor of Cytokine Signalling-2 (SOCS2) and its role in neuronal development and function
-
批准号:nhmrc : 208918
-
项目类别:NHMRC Project Grants
-
资助金额:$30.14万
-
财政年份:2002
-
负责人:A/Pr Ann Turnley
-
依托单位:
国内基金
海外基金
登录
查看更多内容
脊髓新鉴定SNAPR神经元相关环路介导SCS电刺激抑制恶性瘙痒
-
批准号:82371478
-
项目类别:面上项目
-
资助金额:48.00万元
-
批准年份:2023
-
负责人:焦英甫
-
依托单位:
mt DNA/AIM2 inflammasome/ neuronal pyroptosis途径参与创伤性颅脑损伤后认知功能障碍发生的作用机制研究
-
批准号:
-
项目类别:省市级项目
-
资助金额:10.0万元
-
批准年份:2022
-
负责人:盛江涛
-
依托单位:
Tousled like kinase介导青光眼中视网膜神经节细胞死亡的作用和机制
-
批准号:32000518
-
项目类别:青年科学基金项目
-
资助金额:16.0万元
-
批准年份:2020
-
负责人:赵春月
-
依托单位:
去乙酰化酶SIRT1在前体mRNA可变剪切中的作用及其生理病理效应研究
-
批准号:31970691
-
项目类别:面上项目
-
资助金额:58.0万元
-
批准年份:2019
-
负责人:张胜萍
-
依托单位:
脑梗塞运动性失语后语言功能恢复机制的fMRI功能连接研究
-
批准号:30700193
-
项目类别:青年科学基金项目
-
资助金额:18.0万元
-
批准年份:2007
-
负责人:张权
-
依托单位: