The role of neuronal hyperactivity and neurotrophic factor signalling in synaptogenesis, dendrogenesis and neuron death in motor neuron disease

神经元过度活跃和神经营养因子信号传导在运动神经元疾病突触发生、树突发生和神经元死亡中的作用

• 批准号: nhmrc : 1065884
• 负责人: A/Pr Ann Turnley
• 金额: $ 46.7万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-neuronal-hyperactivity-neuron-disease/455203
• 关键词: role; neuronal; hyperactivity; neurotrophic; factor

Using mice with mutant genes causing amyotrophic lateral sclerosis, we will test whether motor neuron hyper-excitability during early development causes excessive synapse and dendrite formation, ultimately leading to neuronal death. We will also test whether activity-dependent secretion of neurotrophic factors and activation of their receptors plays a role in this disease. This will show whether neuronal hyper-activity and neurotrophic factor signaling plays a causal role in this disease.

使用突变基因导致肌萎缩侧索硬化症的小鼠，我们将测试早期发育过程中运动神经元的过度兴奋是否会导致过度的突触和树突形成，最终导致神经元死亡。我们还将测试是否活动依赖性分泌的神经营养因子及其受体的激活在这种疾病中发挥作用。这将显示神经元过度活跃和神经营养因子信号传导是否在这种疾病中起因果作用。