A liquid injection field desorption ionization source for the mass spectrometric analysis of non-polar, air-sensitive compounds

用于非极性空气敏感化合物质谱分析的液体注入场解吸电离源

• 批准号: 389483-2010
• 负责人: McIndoe, Scott
• 金额: $ 5.09万
• 依托单位: University of Victoria
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=442928
• 关键词: liquid; injection; field; desorption; ionization

Mass spectrometry is a highly sensitive technique that enables the rapid analysis of complex mixtures. All sorts of molecules can be analysed, from volatile organic compounds to massive biomolecules. However, there are some classes of compound that are resistant to analysis because they may be non-polar and: (a) of high molecular weight; (b) paramagnetic; (c) highly air- and moisture-sensitive. Conventional ionization techniques serve these classes of compound poorly, and four researchers at UVic seek to address this weakness by purchasing Canada's first Liquid Introduction Field Desorption Ionization (LIFDI) source. This new technology transforms a practically obsolete, experimentally inconvenient technique (FDI) into a fast, modern means of analyzing materials and providing molecular weight and compositional information on compounds that have proved resistant to other means of characterization. As such, all four applicants expect to be able to not only greatly facilitate and expand their current research but also to rapidly break new ground unexplored by them and others in areas as diverse as direct analysis of complex biodiesel mixtures, characterization of polysilane oligomers and paramagnetic lanthanide complexes, and the determination of the molecular structure of metal complexes of stable radicals.

质谱分析是一种高度灵敏的技术，可以快速分析复杂的混合物。可以分析从挥发性有机化合物到大量生物分子的各种分子。然而，有一些类别的化合物难以分析，因为它们可能是非极性的并且： (a) 高分子量； (b) 顺磁性； (c) 对空气和湿气高度敏感。传统的电离技术对这些类别的化合物效果不佳，维多利亚大学的四名研究人员试图通过购买加拿大第一个液体引入场解吸电离 (LIFDI) 源来解决这一弱点。这项新技术将一种实际上已经过时、实验上不方便的技术 (FDI) 转变为一种快速、现代的材料分析方法，并提供已证明对其他表征方法具有抵抗力的化合物的分子量和成分信息。因此，所有四位申请人都期望不仅能够极大地促进和扩展他们当前的研究，而且能够在复杂生物柴油混合物的直接分析、聚硅烷低聚物和顺磁稀土配合物的表征以及稳定自由基的金属配合物的分子结构的测定等不同领域迅速突破他们和其他人未探索的新领域。