Rapid Field Test for Iodine Levels in Salt

盐中碘含量的快速现场测试

• 批准号: 8392593
• 负责人: BIKAS VAIDYA
• 金额: $ 15万
• 依托单位: LYNNTECH, INC.
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-15 至 2014-01-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8392593
• 关键词: Achievement; Address; Area; Brain Injuries; Chemicals; Child; Chromatography; Colorimetry; Corrosives; Devices; Diet; Dietary Sodium Chloride; Disadvantaged; Disease; Dose; Ensure; Equipment; Flow Injection Analysis; Goals; Goiter; Growth and Development function; Hand; Health; Hearing; Household; Injection of therapeutic agent; Iodides; Iodine; Ions; Laboratories; Life; Light; Liquid substance; Measurement; Mental Retardation; Mentally Disabled Persons; Methods; Monitor; Movement; Oxidants; Phase; Population; Pregnant Women; Procedures; Reading; Reagent; Reducing Agents; Resistance; Risk; Sampling; Small Business Innovation Research Grant; Sodium Chloride; Solutions; Spectrophotometry; Speech; Spontaneous abortion; Standardization; Survival Rate; Testing; Time; Titrations; Water; conditioning; cost effective; design; innovation; iodine deficiency syndrome; iodized salt; nutrition; oxidation; prevent; programs; prototype; quality assurance; rapid technique; stillbirth

DESCRIPTION (provided by applicant): Iodine deficiency is the single most common cause of preventable mental retardation and brain damage in the world. It also decreases child survival, causes goiters, and impairs growth and development. Iodine deficiency in pregnant women causes miscarriages, stillbirths, and other complications. Children with iodine deficiency disorder (IDD) can grow up stunted, mentally retarded, and incapable of normal movements, speech, or hearing. Globally, 2.2 billion people (38% of the world's population) live in areas with iodine deficiency and risk its complications. Iodine deficiency and the problems it causes can be prevented by use of iodized salt and effective monitoring of iodine nutrition. However, the level of iodization of salt should be carefully regulated as inadequate levels in the diet will have no noticeable benefit, while excessive doses are wasteful, and may actually result in detrimental health effects. A reliable, simple, and rapid method is therefore needed for routine monitoring of iodine levels in iodized salt at the manufacturing, distribution, retail and household levels. Currently available methods for determination of iodine levels in salt (e.g. colorimetry, classical titration, flow injection analysis, ion chromatography, and ICP-MS) are either not sufficiently sensitive and/or are laborious, require use of highly corrosive chemicals and/or require specialized and expensive equipment, and therefore are not suitable for field testing. To address this need, Lynntech is proposing to develop a simple innovative method for rapid and accurate measurement of iodine levels in salt, suitable for field testing. This method will utilize convenient, disposable, dry reagent cartridges for sample conditioning and iodine level determination and eliminates the need for use of highly corrosive liquid reagents. To determine the iodine content of a salt sample by Lynntech's method, one will simply dissolve a salt sample in water, pass the solution through the cartridge, and take the reading. During Phase I of the project Lynntech will demonstrate the feasibility of using this innovative method being developed at Lynntech for rapid and accurate determination of iodine level in salt through successful achievement of the following objectives: i). Demonstrate that iodide from iodized salts can be oxidized to iodine using a dried oxidizing agent; ii). Demonstrate that iodate from iodized salts can be reduced to iodine using a dried reducing agent; iii). Demonstrate that the iodine released from the iodized salts can be determined quantitatively by the proposed colorimetric method. PUBLIC HEALTH RELEVANCE: Iodine deficiency and the problems it causes can be prevented by use of iodized salt and effective monitoring of iodine nutrition. Currently available methods for determination of iodine level in salt are either not sufficiently sensitive and/or are laborious, require use of highly corrosive chemicals and/or require specialized and expensive equipment, and therefore, are not suitable for field applications. Lynntech is proposing to develop a simple and accurate method using disposable cartridges for routine monitoring of iodine levels in iodized salt in the field.

描述(申请人提供)：缺碘是世界上可预防的精神发育迟滞和脑损伤的最常见原因。它还会降低儿童存活率，导致甲状腺肿，并损害生长和发育。孕妇缺碘会导致流产、死产和其他并发症。患有缺碘障碍(IDD)的儿童在成长过程中可能发育迟缓、智力低下，无法正常行动、说话或听力。在全球范围内，22亿人(占世界人口的38%)生活在 碘缺乏症及其并发症的风险。通过使用加碘食盐和有效监测碘营养，可以预防碘缺乏症及其引起的问题。然而，盐的加碘水平应该受到仔细的监管，因为饮食中不足的水平将没有明显的好处，而过量的盐是浪费的，实际上可能会导致有害的健康影响。因此，需要一种可靠、简单和快速的方法，在生产、分销、零售和家庭层面对加碘食盐中的碘水平进行常规监测。目前可用的测定食盐中碘含量的方法(例如，比色法，经典的 滴定、流动注射分析、离子色谱和电感耦合等离子体质谱仪)要么灵敏度不够和/或费力，需要使用腐蚀性很强的化学品和/或需要专门而昂贵的设备，因此不适合现场测试。为了满足这一需求，Lynntech正在提议开发一种简单、创新的方法，用于快速准确地测量食盐中的碘水平，适用于现场测试。这种方法将利用 方便、一次性、干燥的试剂盒，用于样品调理和碘含量测定，不需要使用腐蚀性很强的液体试剂。要用Lynntech的方法测定盐样本的碘含量，只需将盐样本溶解在水中，将溶液通过试管，然后获取读数。在项目第一阶段，Lynntech将展示使用Lynntech开发的这一创新方法的可行性，通过成功实现以下目标，快速准确地测定食盐中的碘含量：i)证明加碘盐中的碘可以用干燥的氧化剂氧化成碘；ii)。证明可使用干燥的还原剂将加碘盐中的碘酸盐还原为碘；三)证明用所提出的比色法可以定量地测定加碘食盐释放的碘。 与公共卫生的相关性：通过使用加碘食盐和有效监测碘营养，可以预防缺碘及其引起的问题。目前可用的测定食盐中碘含量的方法要么不够灵敏，要么费力，需要使用腐蚀性很强的化学品和/或需要专门而昂贵的设备，因此不适合现场应用。Lynntech建议开发一种简单而准确的方法，使用一次性墨盒对现场加碘盐中的碘水平进行常规监测。