Rapid Field Test for Iodine Levels in Salt

盐中碘含量的快速现场测试

• 批准号: 8392593
• 负责人: BIKAS VAIDYA
• 金额: $ 15万
• 依托单位: LYNNTECH, INC.
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-15 至 2014-01-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8392593
• 关键词: Achievement; Address; Area; Brain Injuries; Chemicals; Child; Chromatography; Colorimetry; Corrosives; Devices; Diet; Dietary Sodium Chloride; Disadvantaged; Disease; Dose; Ensure; Equipment; Flow Injection Analysis; Goals; Goiter; Growth and Development function; Hand; Health; Hearing; Household; Injection of therapeutic agent; Iodides; Iodine; Ions; Laboratories; Life; Light; Liquid substance; Measurement; Mental Retardation; Mentally Disabled Persons; Methods; Monitor; Movement; Oxidants; Phase; Population; Pregnant Women; Procedures; Reading; Reagent; Reducing Agents; Resistance; Risk; Sampling; Small Business Innovation Research Grant; Sodium Chloride; Solutions; Spectrophotometry; Speech; Spontaneous abortion; Standardization; Survival Rate; Testing; Time; Titrations; Water; conditioning; cost effective; design; innovation; iodine deficiency syndrome; iodized salt; nutrition; oxidation; prevent; programs; prototype; quality assurance; rapid technique; stillbirth

DESCRIPTION (provided by applicant): Iodine deficiency is the single most common cause of preventable mental retardation and brain damage in the world. It also decreases child survival, causes goiters, and impairs growth and development. Iodine deficiency in pregnant women causes miscarriages, stillbirths, and other complications. Children with iodine deficiency disorder (IDD) can grow up stunted, mentally retarded, and incapable of normal movements, speech, or hearing. Globally, 2.2 billion people (38% of the world's population) live in areas with iodine deficiency and risk its complications. Iodine deficiency and the problems it causes can be prevented by use of iodized salt and effective monitoring of iodine nutrition. However, the level of iodization of salt should be carefully regulated as inadequate levels in the diet will have no noticeable benefit, while excessive doses are wasteful, and may actually result in detrimental health effects. A reliable, simple, and rapid method is therefore needed for routine monitoring of iodine levels in iodized salt at the manufacturing, distribution, retail and household levels. Currently available methods for determination of iodine levels in salt (e.g. colorimetry, classical titration, flow injection analysis, ion chromatography, and ICP-MS) are either not sufficiently sensitive and/or are laborious, require use of highly corrosive chemicals and/or require specialized and expensive equipment, and therefore are not suitable for field testing. To address this need, Lynntech is proposing to develop a simple innovative method for rapid and accurate measurement of iodine levels in salt, suitable for field testing. This method will utilize convenient, disposable, dry reagent cartridges for sample conditioning and iodine level determination and eliminates the need for use of highly corrosive liquid reagents. To determine the iodine content of a salt sample by Lynntech's method, one will simply dissolve a salt sample in water, pass the solution through the cartridge, and take the reading. During Phase I of the project Lynntech will demonstrate the feasibility of using this innovative method being developed at Lynntech for rapid and accurate determination of iodine level in salt through successful achievement of the following objectives: i). Demonstrate that iodide from iodized salts can be oxidized to iodine using a dried oxidizing agent; ii). Demonstrate that iodate from iodized salts can be reduced to iodine using a dried reducing agent; iii). Demonstrate that the iodine released from the iodized salts can be determined quantitatively by the proposed colorimetric method. PUBLIC HEALTH RELEVANCE: Iodine deficiency and the problems it causes can be prevented by use of iodized salt and effective monitoring of iodine nutrition. Currently available methods for determination of iodine level in salt are either not sufficiently sensitive and/or are laborious, require use of highly corrosive chemicals and/or require specialized and expensive equipment, and therefore, are not suitable for field applications. Lynntech is proposing to develop a simple and accurate method using disposable cartridges for routine monitoring of iodine levels in iodized salt in the field.

描述（由申请人提供）：碘缺乏症是世界上可预防的精神发育迟滞和脑损伤的最常见原因。它还降低儿童存活率，导致甲状腺肿，并损害生长和发育。孕妇缺碘会导致流产、死胎和其他并发症。患有碘缺乏病（IDD）的儿童在成长过程中可能会发育不良、智力迟钝、无法正常运动、言语或听力。在全球范围内，22亿人（占世界人口的38%）生活在 碘缺乏症及其并发症风险。碘缺乏症及其引起的问题可以通过使用碘盐和有效监测碘营养来预防。然而，应仔细管理食盐的碘化水平，因为饮食中碘化水平不足不会带来明显的好处，而过量则是浪费，实际上可能对健康产生有害影响。因此，需要一种可靠、简单、快速的方法，用于在生产、分销、零售和家庭层面对碘盐中的碘含量进行常规监测。目前可用于测定盐中碘含量的方法（例如比色法、经典的 滴定、流动注射分析、离子色谱法和ICP-MS）或者不够灵敏和/或费力，需要使用高度腐蚀性的化学品和/或需要专门且昂贵的设备，因此不适合现场测试。为了满足这一需求，Lynntech正在开发一种简单的创新方法，用于快速准确地测量盐中的碘含量，适用于现场测试。该方法将利用 方便、一次性、干燥的试剂盒，用于样品调节和碘水平测定，无需使用高腐蚀性液体试剂。为了通过Lynntech的方法确定盐样品中的碘含量，人们将简单地将盐样品溶解在水中，使溶液通过盒，并读取阅读。 在项目的第一阶段，Lynntech将通过成功实现以下目标，证明使用Lynntech开发的这种创新方法快速准确地测定盐中碘含量的可行性：i）。证明碘盐中的碘化物可以用干燥的氧化剂氧化成碘; ii）.证明碘盐中的碘酸盐可以用干燥的还原剂还原为碘; iii）.证明可通过拟定的比色法定量测定碘盐中释放的碘。 公共卫生相关性：碘缺乏症及其引起的问题可以通过使用碘盐和有效监测碘营养来预防。目前可用的用于测定盐中碘水平的方法要么不够灵敏和/或费力，需要使用高度腐蚀性的化学品和/或需要专门且昂贵的设备，因此不适合现场应用。Lynntech公司建议开发一种简单而准确的方法，使用一次性检测盒在现场对碘盐中的碘含量进行常规监测。