Upgrades for 500 MHz spectrometer to enable protein NMR spectroscopy

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Nuclear magnetic resonance (NMR) spectroscopy can be used to elucidate information about the 3-dimensional structural of important biological molecules, how their structure changes in time, and their interactions with other molecules, such as drugs. At the University of Toronto Mississauga, there are three researchers who use NMR spectroscopy to study medically important biological molecules. Their studies involve studies of complex macromolecular systems, which require significant access to high field NMR spectrometers. Currently, there is only one high field spectrometer (600 MHz) at UTM capable of biomolecular NMR experiments. Funds are requested for computer upgrades and associated software to render the second high field instrument, a 500 MHz spectrometer, capable of complicated biolomecular NMR experiments. We also request funding for an uninterruptable power supply (UPS) to protect against intermittent power failures, which could severely damage the instrument and are problematic for acquiring biomolecular NMR experiments that normally take many hours or days, making a UPS necessary. By equipping the 500 MHz instrument for protein NMR studies, we can create an NMR center that better accommodates the needs of the NMR groups.