Upgrades for 500 MHz spectrometer to enable protein NMR spectroscopy

核磁共振波谱可以用来阐明有关重要生物分子的三维结构、它们的结构如何随时间变化以及它们与其他分子(如药物)相互作用的信息。在密西索加多伦多大学，有三名研究人员使用核磁共振光谱学来研究具有重要医学意义的生物分子。他们的研究涉及复杂的大分子系统的研究，这需要大量使用高场核磁共振光谱仪。目前，UTM只有一台高场光谱仪(600 MHz)能够进行生物分子核磁共振实验。需要资金用于计算机升级和相关软件，以使第二台高场仪器--500兆赫光谱仪--能够进行复杂的生物分子核磁共振实验。我们还要求为不间断电源(UPS)提供资金，以防止间歇性电源故障，间歇性电源故障可能会严重损坏仪器，并且对于获取通常需要数小时或数天的生物分子核磁共振实验来说是有问题的，因此需要使用UPS。通过装备用于蛋白质核磁共振研究的500 MHz仪器，我们可以创建一个更好地满足核磁共振小组需求的核磁共振中心。

Nuclear magnetic resonance (NMR) spectroscopy can be used to elucidate information about the 3-dimensional structural of important biological molecules, how their structure changes in time, and their interactions with other molecules, such as drugs. At the University of Toronto Mississauga, there are three researchers who use NMR spectroscopy to study medically important biological molecules. Their studies involve studies of complex macromolecular systems, which require significant access to high field NMR spectrometers. Currently, there is only one high field spectrometer (600 MHz) at UTM capable of biomolecular NMR experiments. Funds are requested for computer upgrades and associated software to render the second high field instrument, a 500 MHz spectrometer, capable of complicated biolomecular NMR experiments. We also request funding for an uninterruptable power supply (UPS) to protect against intermittent power failures, which could severely damage the instrument and are problematic for acquiring biomolecular NMR experiments that normally take many hours or days, making a UPS necessary. By equipping the 500 MHz instrument for protein NMR studies, we can create an NMR center that better accommodates the needs of the NMR groups.