Modular microscope with tetrade micromanipulator for functionnal studies of DNA repair activities at chromosomal termini.

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The termini of linear eukaryotic chromosomes, known as telomeres, resemble DNA double-helix interruptions, the most dangerous among DNA lesions that threaten the integrity of the genome. While chromosomal breaks are immediately subjected to DNA repair, such repair attempts at telomeres can lead to loss of genetic information, genome instability, cellular transformation and, ultimately, cell death. Paradoxically, several proteins involved in sensing and repair of chromosomal breaks reside at telomeres and assist in their maintenance. Our research goal is to define the molecular features that distinguish telomeres from genomic DNA breaks and how DNA repair activities are controlled at telomeres throughout the cell cycle.