A high-pressure liquid chromatography instrument

一种高压液相色谱仪

• 批准号: 390364-2010
• 负责人: Gleason, James
• 金额: $ 4.97万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=443173
• 关键词: pressure; liquid; chromatography; instrument

Our research group has developed a large research thrust in the area of hybrid drug development. These molecules combine inhibitory activity for the histone deacetylase inhibitor with either agonism or antagonism for nuclear receptors (vitamin D, estrogen and retinoic acid receptors) and represent exciting new potential therapies for cancer and tuberculosis. A key to the analysis of these new molecules is having analytically pure samples for testing both against cells in culture and in animal xenografts. We urgently require a high-pressure liquid chromatography instrument for purification of our hybrid molecules so that we can continue and expand this important research project.

我们的研究小组在混合药物开发领域开展了大量的研究工作。 这些分子结合了对组蛋白脱乙酰酶抑制剂的联合收割机抑制活性和对核受体（维生素D、雌激素和视黄酸受体）的激动或拮抗作用，代表了令人兴奋的癌症和结核病的新的潜在疗法。 分析这些新分子的关键是具有分析纯样品，用于测试培养物和动物异种移植物中的细胞。 我们迫切需要一种高压液相色谱仪来纯化我们的混合分子，以便我们能够继续和扩大这一重要的研究项目。