Using influenza vaccination to understand and improve anti-viral immunity in COPD

慢性阻塞性肺疾病（COPD）是世界范围内死亡率和发病率的主要原因之一。肺部感染常常使慢性阻塞性肺病患者非常不舒服。我们最近的研究表明，在许多COPD患者中，流感疫苗接种诱导抗体反应较差。这项研究将研究为什么会出现这种情况，以及如何恢复正常的免疫功能。在计划的最后一年，我们会评估将流感疫苗接种剂量加倍是否有帮助。

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of mortality and morbidity worldwide. Lung infections often make those afflicted by COPD very unwell. We have recently shown that influenza vaccination induces a poor antibody response in many COPD patients. This study will examine why this is the case, and what can be done to restore normal immune function. In the final year of the Project, we will assess whether doubling the dose of influenza vaccination is helpful.