Using influenza vaccination to understand and improve anti-viral immunity in COPD

使用流感疫苗接种来了解和提高慢性阻塞性肺病患者的抗病毒免疫力

• 批准号: nhmrc : 1081433
• 负责人: A/Pr Louis Irving
• 金额: $ 87.79万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/using-influenza-vaccination-immunity-copd/518810
• 关键词: Using; influenza; vaccination; understand; improve

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of mortality and morbidity worldwide. Lung infections often make those afflicted by COPD very unwell. We have recently shown that influenza vaccination induces a poor antibody response in many COPD patients. This study will examine why this is the case, and what can be done to restore normal immune function. In the final year of the Project, we will assess whether doubling the dose of influenza vaccination is helpful.

慢性阻塞性肺疾病（COPD）是世界范围内死亡率和发病率的主要原因之一。肺部感染经常使那些患有COPD的人非常不适。我们最近的研究表明，流感疫苗接种在许多COPD患者中诱导了较差的抗体应答。这项研究将探讨为什么会出现这种情况，以及如何恢复正常的免疫功能。在计划的最后一年，我们会评估把流感疫苗注射的剂量增加一倍是否有帮助。